I'd spend it.

I love the designs, and the Bill of rights on the back, but where's the Second Amendment? Can we reintroduce the $500 bill and use that on the back? Put Alexander Hamilton on the bill for ironic purposes.
I'm holding out for one and two dollar coins. Canada totally corrupted me on this.
Edit The first and second amendments are on the $5. I still think the Second Amendment deserves it's own bill.
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Maybe each dollar bill should be different color? Say a pink $5, a yellow $10, a green $20, a blue $50, a tan $100, and an orange $500?
Of course, perhaps the biggest problem with counterfeiting is that old bills are still legal tender - why try to pass off a new bill when you can try to pass off an old bill?
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Each bill on the site has a differently colored strip.
When we introduce new money the Federal Reserve institutes a replacement policy. Essentially, when old bills come into a Reserve bank, they are replaced in circulation with a new bill and destroyed. Add in the short lifespan of paper currency (under two years for the most commonly used denominations) and you quickly replace the notes in circulation.