She's the white, thin, female version of Uncle Ruckus: An overweight black man with a grotesque appearance who idolizes white culture. Ruckus is self-hating, dissassociating himself from his African-American heritage as best he can, and instead championing whatever small traces of Native American and Irish ancestry he may have. His greatest wish is that black people were still enslaved, because he believes that they were better off that way. He claims to have a mythical disease called "re-vitiligo" ("the reverse of what Michael Jackson has," he always retorts). Ironically, he is the darkest-skinned character on the show. His character is a hyperbolic parody of the self-hating black man, and is named after Joel Chandler Harris' Uncle Remus character.
Uh oh, a Boondocks reference